JMay 27, 2020 The chromosomal sex of the embryo is established at fertilization With the other members of the epidermal growth factors family, it binds to the epidermal growth factor receptor (EGFR)It promotes changes in the reproductive tract (vagina, cervix, uterus, and oviducts) and the mammary glands that prepare the female for gamete transport and fertilization and for potential pregnancy and lactation Pache, in Encyclopedia of Respiratory Medicine, 2006 Epidermal growth factor (EGF) was the first growth factor to be discovered Sex differentiation involves a series of events whereby the sexually indifferent gonads and genitalia progressively acquire male or female characteristics However, 6 weeks elapse in humans before the first signs of sex differentiation are noticed EGF precursor is a transmembranous glycoprotein from which the active EGF is cleaved by an endopepsidaseC In addition, estradiol exerts paracrine and autocrine effects within developing preovulatory follicles that promote their development Believed initially to be governed entirely